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Fibrohistiozytäre Tumoren der Haut

Eine heterogene Gruppe oberflächlich lokalisierter mesenchymaler Neoplasien

Fibrohistiocytic tumors of the skin

A heterogeneous group of superficially located mesenchymal neoplasms

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Zusammenfassung

Sogenannte fibrohistiozytäre Tumoren der Haut umfassen ein klinisch-pathologisch heterogenes Spektrum oberflächlich lokalisierter Tumoren, bei denen oft eine fibroblastische und/oder myofibroblastische Differenzierung nachweisbar ist. In der vorliegenden Übersicht werden klinisch-pathologisch relevante Formvarianten des Dermatofibroms und des Dermatofibrosarcoma protuberans vorgestellt und ihre Differenzialdiagnosen diskutiert. Weiterhin werden die klinisch-pathologischen Befunde des atypischen Fibroxanthoms, des angiomatoiden fibrösen Histiozytoms, des plexiformen fibrohistiozytischen Tumors und des pleomorphen dermalen Sarkoms vorgestellt und die differenzialdiagnostisch wichtigen Entitäten abgegrenzt.

Abstract

So-called fibrohistiocytic tumors of the skin comprise a heterogeneous spectrum of superficially located neoplasms that often show fibroblastic and/or myofibroblastic differentiation. In this review clinicopathologically important variants of dermatofibroma and dermatofibrosarcoma protuberans and their differential diagnoses are discussed in detail. In addition, the clinicopathological features of atypical fibroxanthoma, angiomatoid fibrous histiocytoma, plexiform fibrohistiocytic tumors and pleomorphic dermal sarcoma are presented. Entities that have to be considered in the differential diagnosis are also mentioned.

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Einhaltung ethischer Richtlinien

Interessenkonflikt. T. Mentzel gibt an, dass kein Interessenkonflikt besteht. Dieser Beitrag beinhaltet keine Studien an Menschen oder Tieren.

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  1. Dermatopathologie Bodensee, Siemensstr. 6/1, 88048, Friedrichshafen, Deutschland

    T. Mentzel

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Mentzel, T. Fibrohistiozytäre Tumoren der Haut. Pathologe 36, 79–88 (2015). https://doi.org/10.1007/s00292-014-2032-x

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