Abstract
Odontogenic myxoma (OM) is an uncommon benign odontogenic tumor arising in the jaw. Though it has slight histologic overlap with other entities, definitive diagnosis is imperative considering the tumor’s aggressive nature, high recurrence rate, and necessity of radical surgical intervention in large-sized lesions. With IRB approval, a retrospective search of the University of Florida College of Dentistry Oral Pathology Biopsy Service archives from 1994 to 2017 for diagnosis of OM of the jaw was performed. Biopsy reports and original slides for each case were assessed and reviewed along with any accompanying radiographs to confirm the diagnosis. Immunohistochemical staining was utilized to exclude entities with histologic overlaps, such as intraosseous myxoid neurofibroma. A total of 38 cases were included. The patients’ age ranged from 6 to 84 years, with a mean age of 37.47 years. Females comprised two-thirds of the cases (n = 25) versus males (n = 13). The mandible was the most affected at 60.5% (n = 23), followed by maxilla 39.4% (n = 15). Posterior jaw involvement was higher than anterior in both the mandible (n = 20 versus n = 3) and the maxilla (n = 11 versus n = 4). Most lesions presented clinically as expansile masses with variable radiographic appearance. The clinical impression from submitting providers included “gelatinous masses”, abscesses, odontogenic lesions, fibro-osseous lesions, soft tissue or bone neoplasms, and reactive gingival lesions. A consensus of odontogenic myxoma as a diagnosis was rendered for 30 cases (79%), while in 8 cases (21%) that exhibited a more fibrous stroma was identified as fibromyxoma. OM may exhibit a varied demographic and clinical profile with a wide spectrum of histologic presentations. Pathologists should be sentient of this variability in order to arrive at an accurate diagnosis and correctly manage these patients.
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References
Thoma KH, Goldman HM. Central myxoma of the jaw. Oral Surg Oral Med Oral Pathol. 1947;33(7):B532–40.
Brannon RB. Central odontogenic fibroma, myxoma (odontogenic myxoma, fibromyxoma), and central odontogenic granular cell tumor. Oral Maxillofac Surg Clin North Am. 2004;16(3):359–74.
Simon EN, Merkx MA, Vuhahula E, Ngassapa D, Stoelinga PJ. Odontogenic myxoma: a clinicopathological study of 33 cases. Int J Oral Maxillofac Surg. 2004;33(4):333–7.
Titinchi F, Hassan BA, Morkel JA, Nortje C. Odontogenic myxoma: a clinicopathological study in a South African population. J Oral Pathol Med. 2016;45(8):599–604.
Lima-Verde-Osterne R, Turatti E, Cordeiro-Teixeira R, Barroso-Cavalcante R. The relative frequency of odontogenic tumors: A study of 376 cases in a Brazilian population. Med Oral Patol Oral Cir Bucal. 2017;22017:e193–200.
Buchner A, Merrell PW, Carpenter WM. Relative frequency of central odontogenic tumors: a study of 1,088 cases from Northern California and comparison to studies from other parts of the world. J Oral Maxillofac Surg. 2006;64(9):1343–52.
Vasconcelos ACU, Silveira FM, Gomes APN, Tarquinio SBC, Sobral APV, de Arruda JAA, et al. Odontogenic myxoma: a 63-year retrospective multicenter study of 85 cases in a Brazil population and a review of 999 cases from literature. J Oral Pathol Med. 2018;47(1):71–7.
Adebayo ET, Ajike SO, Adekeye EO. A review of 318 odontogenic tumors in Kaduna, Nigeria. J Oral Maxillofac Surg. 2005;63(6):811–9.
Oginni FO, Stoelinga PJ, Ajike SA, Obuekwe ON, Olokun BA, Adebola RA, et al. A prospective epidemiological study on odontogenic tumours in a black African population, with emphasis on the relative frequency of ameloblastoma. Int J Oral Maxillofac Surg. 2015;44(9):1099–105.
Johnson NR, Gannon OM, Savage NW, Batstone MD. Frequency of odontogenic cysts and tumors: a systematic review. J Investig Clin Dent. 2014;5(1):9–14.
Kangur TT, Dahlin DC. Myxomatous tumors of the jaws. J Oral Surg. 1975;33(7):523–8.
Mehendiratta M, Rehani S, Solomon MC. The histological spectrum of myxoma, myxofibroma /fibromyxoma and odontogenic fibroma- “a chicken and egg situation". IOSR J Dent Med Sci. 2012;1:3–5.
Chrcanovic BR, Gomez RS. Odontogenic myxoma: an updated analysis of 1,692 cases reported in the literature. Oral Dis. 2019;25(3):676–83.
Kaffe I, Naor H, Buchner A. Clinical and radiological features of odontogenic myxoma of the jaws. Dentomaxillofac Radiol. 1997;26(5):299–303.
Martinez-Mata G, Mosqueda-Taylor A, Carlos-Bregni R, de Almeida OP, Contreras-Vidaurre E, Vargas PA, et al. Odontogenic myxoma: clinico-pathological, immunohistochemical and ultrastructural findings of a multicentric series. Oral Oncol. 2008;44(6):601–7.
Li TJ, Sun LS, Luo HY. Odontogenic myxoma: a clinicopathologic study of 25 cases. Arch Pathol Lab Med. 2006;130(12):1799–806.
Zhang J, Wang H, He X, Niu Y, Li X. Radiographic examination of 41 cases of odontogenic myxomas on the basis of conventional radiographs. Dentomaxillofac Radiol. 2007;36(3):160–7.
Meleti M, Giovannacci I, Corradi D, Manfredi M, Merigo E, Bonanini M, et al. Odontogenic myxofibroma: a concise review of the literature with emphasis on the surgical approach. Med Oral Patol Oral Cir Bucal. 2015;12015:e16.
Keszler A, Dominguez FV, Giannunzio G. Myxoma in childhood: an analysis of 10 cases. J Oral Maxillofac Surg. 1995;53(5):518–21.
Wright JM, Vered M. Update from the 4th edition of the world health organization classification of head and neck tumours: odontogenic and maxillofacial bone tumors. Head Neck Pathol. 2017;11(1):68–77.
Takahashi Y, Tanaka K, Hirai H, Marukawa E, Izumo T, Harada H. Appropriate surgical margin for odontogenic myxoma: a review of 12 cases. Oral Surg Oral Med Oral Pathol Oral Radiol. 2018;126(5):404–8.
Noffke CE, Raubenheimer EJ, Chabikuli NJ, Bouckaert MM. Odontogenic myxoma: review of the literature and report of 30 cases from South Africa. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2007;104(1):101–9.
Barros RE, Dominguez FV, Cabrini RL. Myxoma of the jaws. Oral Surg Oral Med Oral Pathol. 1969;27(2):225–36.
Lo Muzio L, Nocini P, Favia G, Procaccini M, Mignogna MD. Odontogenic myxoma of the jaws: a clinical, radiologic, immunohistochemical, and ultrastructural study. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 1996;82(4):426–33.
Che Z, Nam W, Park WS, Kim HJ, Cha IH, Kim HS, et al. Intraosseous Nerve Sheath Tumors in the Jaws. Yonsei Med J. 2006;47(2):264–70.
Meredith DM, Fletcher CDM, Jo VY. Chondromyxoid fibroma arising in craniofacial sites: a clinicopathologic analysis of 25 cases. Am J Surg Pathol. 2018;42(3):392–400.
Subramaniam SS, Heggie AA, Kumar R, Shand JM. Odontogenic myxoma in the paediatric patient: a review of eight cases. Int J Oral Maxillofac Surg. 2016;45(12):1614–7.
Batsakis JG. Myxomas of soft tissues and the facial skeleton. Ann Otol Rhinol Laryngol. 1987;96(5):618–9.
Saalim M, Sansare K, Karjodkar FR, Farman AG, Goyal SN, Sharma SR. Recurrence rate of odontogenic myxoma after different treatments: a systematic review. Br J Oral Maxillofac Surg. 2019;57(10):985–91.
You Z, Liu SP, Du J, Wu YH, Zhang SZ. Advancements in MAPK signaling pathways and MAPK-targeted therapies for ameloblastoma: a review. J Oral Pathol Med. 2019;48:201–5.
Pereira NB, Bastos VC, de Souza JC, Diniz MG, Vitorio JG, Kitten GT, et al. First insights for targeted therapies in odontogenic myxoma. Clin Oral Investig. 2019. https://doi.org/10.1007/s00784-019-03107-4.
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Banasser, A.M., Bawazir, M.M., Islam, M.N. et al. Odontogenic Myxoma: A 23-Year Retrospective Series of 38 Cases. Head and Neck Pathol 14, 1021–1027 (2020). https://doi.org/10.1007/s12105-020-01191-7
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DOI: https://doi.org/10.1007/s12105-020-01191-7