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1977, European Archives of Oto-rhino-laryngology
Case-report about a 56 year old white female patient with pachydermia laryngis and hirsutism, successfully treated with cyproterone-acetate, a testosterone antagonist. The significance of androgenic hormones for the development of epithelial changes in the female larynx is emphasized. The administration of antiandrogenic substances as a new therapeutic measure is discussed. Es wird über eine 56jährige Patientin mit Pachydermia laryngis und Hirsutismus berichtet, die erfolgreich mit dem Testosteron-Antagonisten Cyproteronacetat behandelt werden konnte. An Hand dieses Falles wird die Bedeutung androgener Hormone für die Genese von Epithelveränderungen am weiblichen Kehlkopf unterstrichen und die Anwendung antiandrogener Substanzen als neuartige therapeutische Möglichkeit diskutiert.
Endocrine Related Cancer
Disappearance of a virilizing adrenal tumor following therapy with cyproterone acetate2005 •
Journal of Dermatological Treatment
Cyproterone acetate or drospirenone containing combined oral contraceptives plus spironolactone or cyproterone acetate for hirsutism: Randomized comparison of three regimens2012 •
Innovative Rheumatology
Andrographolide a New Potential Drug for the Long Term Treatment of Rheumatoid Arthritis Disease2013 •
1999 •
Objective: To compare triptorelin, cyproterone acetate (CPA), and flutamide, in combination with an oral contraceptive, in the treatment of hirsutism.Design: Prospective randomized study.Setting(s): Tertiary care hospital.Patient(s): Thirty-nine hirsute women with idiopathic or functional ovarian hyperandrogenism.Intervention(s): Patients were randomly assigned to receive triptorelin (3.75 mg IM every 28 days), CPA (100 mg/d orally on days 1–10 of the menstrual cycle), or flutamide (250 mg orally twice daily). All the patients also received a triphasic oral contraceptive.Main Outcome Measure(s): Before and after 3 and 9 months of treatment, the Ferriman-Gallwey score, hepatic function, and gonadal and adrenal steroid profiles were evaluated.Results: Thirty-three patients completed the 9-month study period. The Ferriman-Gallwey score decreased in all the groups. In the patients treated with CPA or flutamide, a decrease in the hirsutism score was noted as soon as after 3 months of treatment. This decrease was more pronounced after 9 months of treatment, especially in the patients who received flutamide, who had lower hirsutism scores compared with the other treatment groups. None of the patients had abnormal liver function test results. There was a mild increase in serum lipid concentrations, mostly in the group treated with triptorelin.Conclusion(s): Triptorelin, CPA, and flutamide are effective drugs for the treatment of hirsutism. Flutamide results in a greater reduction in the hirsutism score, but CPA also offers satisfactory results at a much lower cost. Triptorelin has no advantages over flutamide and CPA, and is the most expensive of the three drugs tested.
European Journal of Endocrinology
Changing your sex changes your brain: influences of testosterone and estrogen on adult human brain structure2006 •
… Department of Public …
Endocrine therapy for transgender adults in British Columbia: Suggested guidelines2006 •
Pak. J. Biotechnol.
CYTOGENETIC ACTIVITY AND ANTIOXIDANT ROLE OF FLAXSEEDS (LINUM USITATISSIMUM L.) EXTRACT IN MALE ALBINO RATS TREATED WITH CYPROTERONE ACETATE2018 •
Objectives Investigation the cytogenetic activity and antioxidant role of methanolic extract of flaxseeds in male albino rats treated with cyproterone acetate. Methods The first part contains a phytochemical analysis of flaxseeds 20% methanolic extract include: Thin layer chromatography (TLC), determination of active compounds, and antioxidant activity of flaxseeds extract. The second part was experimental groups include 35 rats divided randomly into 7 groups: first and second groups treated with distilled water (D.W) and corn oil respectively as control groups, cyproterone acetate (CPA) (10 mg/kg/day) group, flaxseeds extract (250 and 500 mg/kg/day) respectively, and groups treated both CPA with flaxseeds extract with the same doses above respectively. After 50 days, the cytogenetic study including mitotic index (MI) and chromosomal aberrations (CA) of bone marrow cells in addition to the levels of DNA fragmentation in both white blood cells (WBC) and testes tissues was assessed. Results Presence of some phytochemical and antioxidant compounds in 20% methanolic extract of flaxseeds. CPA group had a significant increase (P≤0.05) in MI and CA compared to both D.W and corn oil control groups and has a high level of DNA fragmentation in both WBC and testes tissue. In contrast, flaxseeds extract alone or with CPA did not induce a significant difference in MI and CA but it considered as significant decreasing (P≤0.05) when compared with CPA group. Furthermore, both groups treated with flaxseeds 250 and 500 mg/kg/day alone did not record any fragmentation of DNA of WBC but caused fragmentation of DNA of testes tissue. While a decreased level of DNA fragmentation of WBC and testes tissue was noted in CPA with flaxseeds treated groups when compared with the CPA group. Conclusions The methanolic extract of flaxseeds had a cytogenetic activity to suppresses mitogenic and genotoxic effects of CPA via its antioxidant properties.
Clinical Endocrinology
Mortality and morbidity in transsexual subjects treated with cross-sex hormones1997 •
Dermatologic Clinics
Glucocorticoid and Sex Hormone Receptors: Clinical Implications and Therapeutic Relevance2007 •
Arthritis and Rheumatism
Hormonal modulation in systemic lupus erythematosus. Preliminary clinical and hormonal results with cyproterone acetate1985 •
2015 •
2004 •
American Journal of Clinical Dermatology
Dermatologic Manifestations of Polycystic Ovary Syndrome2007 •
Molecular Medicine Reports
Age-dependent endocrine disorders involved in the pathogenesis of refractory acne in women2016 •
International journal of women's health
Treatment options for polycystic ovary syndrome2011 •
BJOG: An International Journal of Obstetrics and Gynaecology
The long term health consequences of polycystic ovary syndrome2000 •
Ultrasound in Obstetrics and Gynecology
Ultrasonographic and color Doppler analysis in the treatment of polycystic ovary syndrome1998 •
Clinics in dermatology
Rational investigations in the diagnosis and management of women with hirsutism or androgenetic alopecia2001 •
Croatian medical journal
Antiandrogens in hormonal contraception limit muscle strength gain in strength training: comparison study2003 •
Fertility and Sterility
Use of cyproterone acetate, finasteride, and spironolactone to treat idiopathic hirsutism2003 •
Facts, views & vision in ObGyn
Gynaecological aspects of the treatment and follow-up of transsexual men and women2010 •
Journal of Sex & Marital Therapy
Sexual Desire in Women Presenting for Antiandrogen Therapy2003 •
Journal of Voice
The Effect of Oxandrolone on Voice Frequency in Growth Hormone-Treated Girls With Turner Syndrome2011 •
British Journal of Dermatology
Female pattern hair loss, sebum excretion and the end-organ response to androgens2006 •
Journal of the American Academy of Dermatology
Polycystic ovary syndrome: A review for dermatologists2014 •
Hormones and Behavior
Historical perspective: Hormonal regulation of behaviors in amphibians2005 •
Middle East Fertility Society Journal
Evaluation of serum PSA after cyproterone compound treatment compared with oral contraceptive pill in hirsute polycystic ovary syndrome patients2010 •
2005 •
The Journal of Steroid Biochemistry and Molecular Biology
Is plasma 5α-androstane 3α, 17β-diol glucuronide a biochemical marker of hirsutism in women?1991 •
Biological Psychiatry
High-Dose Testosterone Treatment Increases Serotonin Transporter Binding in Transgender People2014 •
Nature Reviews Endocrinology
Hyperinsulinaemic androgen excess in adolescent girls2014 •
Journal of Men's Health
Characterization of bone mineral density in male-to-female transsexuals receiving treatment for reassignment surgery: 15 years of follow-up2008 •
International journal of occupational medicine and environmental health
Treatment of Reincke's edema among different professional groups: presentation of results2004 •
2003 •