Szabolcs Béni’s Post

Join us this afternoon at 3 PM ET as Dr. Dan Kalish explains how environmental toxin exposure damages metabolism and how practitioners can use the OMX® Organic Metabolomics tests to assess this damage. #OMXtest #functionalmedicine #detoxification #functionalmedicine #GIMAP #organicacids

Glad to share our latest paper published on AEM. Please check here: https://lnkd.in/dkJzQzBg The questions is: how can extracellular electron transfer (EET) of Lactococcus lactis be enhanced? In this paper, we try to figure out the underlying reason of a Lactococcus lactis mutant with enhanced EET ability. A novel type-II NADH dehydrogenase is experimentally proven to participate in both EET and respiration of L. lactis for the first time. Besides, this novel NoxB-type NADH is found to be widely distributed among gut microorganisms.

I am excited to share my first author publication from my PhD research. This work is an extension of a previous work in our lab by my colleague ANDRE VIEIRA, that uncovered a novel role for monomethyl branched-chain fatty acids (mmBCFAs) in the response to elevated glucose diet by C. elegans. In this current work, we show that the role of mmBCFA in glucose stress response is through the production of a unique class of lipid known as Glucosylceramides. Using targeted lipidomics and survival assays we have demonstrated that compromising the production glucosylceramides leads to a shortened lifespan under glucose stress.  https://lnkd.in/ejrfayvV #work #research #phd #publication #lipidomics

My first paper as 1st author was released last year and I still can't believe it! If you like Synthetic Biology and Metabolic Engineering take a look on how we reversed the metabolism of Pseudomonas putida in order to make it produce an important antioxidant from glycerol:

A synthetic pyrethroid used as an insecticide is called lambda cyhalothrin LCT . Investigation of LCTs effects on neurobehavioral and reproductive effects was the studys main objective. Therefore, the existing study was designed to investigate the effect of LCT on the reproductive and neurobehavioral effects. In this study found reproductive toxicity, hepatotoxicity, nephrotoxicity, and splenotoxicity and also showed reduced testosterone levels and ovarian alteration. Also found neurotransmitter levels and AChE and Na K ATPase activities are suppressed. by Gaurav Kumar | Navodita Priyadarshani "A Review on Reproductive and Neurobehavioral Effect of Pesticide lambda-cyhalothrin" Published in International Journal of Trend in Scientific Research and Development (ijtsrd), ISSN: 2456-6470, Volume-7 | Issue-2 , April 2023, URL: https://lnkd.in/dHbQ-dJn Paper URL: https://lnkd.in/dHjyNFUS

Are anaerobic fungi crucial hidden players of microbiomes in anoxic environment? A new review article written by E. Hoque and J. Fritscher (https:/https://lnkd.in/eyffDeKT, Cri. Rev. Microbiol.) gives insight into an exciting research field of microbiology, biotechnolgy and biogeochemistry.

🔬 I'm thrilled to announce the publication of my latest article "The Effects of Cellular Membrane Damage on the Long-Term Storage and Adhesion of Probiotic Bacteria in Caco-2 Cell Line". This study sheds new light on the relationship between cellular damage (measured using imaging flow cytometry) and adhesion of the bacteria to the epithelium. It also highlights the influence of storage conditions and coating on their shelf-life. Full article can be accessed below. #biotech #foodtechnology #flowcytometry #probiotics

I am pleased to announce that my first research paper has finally been published ❕ As evidence accumulates that certain metabolism-disrupting chemicals may promote obesity in humans, we have developed a potential New Approach Method for assessing the adipogenic effects of environmental chemicals by using metabolomics in human SGBS adipocytes. We applied this method to evaluate the effects of the DEHP substitute plasticizer DINCH and its primary metabolite MINCH on human adipocyte metabolism and potential adipogenesis-promoting effects. If you are interested in this method and the results, please check out my paper. https://lnkd.in/ennFDsbB

Thank Allah, another article has been published in Elsevier journal, ISI Q3. Important results: 1-The major constituents of lavender essential oils (Lavandula angustifolia) were linalool (28.94%), linalyl acetate (19.95%), and caryophyllene (6.46%). 2-The EO's antimicrobial activities were evaluated against various microorganisms, including bacteria and yeast, and showed remarkable antimicrobial activity. 3-The results indicated that lavender EO has significant antidiabetic activity. 4-The EO exhibited significant antioxidant properties. 5- Molecular docking and ADMET (Absorption, Distribution, Metabolism, Excretion, and Toxicity) analysis were used to validate and support the experimental findings. The publication is not freely accessible, but you can obtain a complimentary download for the next 50 days through this link: https://lnkd.in/dSkRrbNc

Sulfur Metabolism as a Promising Source of New Antifungal Targets Fungal infections are a growing threat to human health. Despite their clinical relevance, there is a surprisingly limited availability of clinically approved antifungal agents, which is seriously aggravated by the recent appearance and fast spread of drug resistance. It is therefore clear that there is an urgent need for novel and efficient antifungals. In this context, metabolism is recognized as a promising source for new antifungal targets and, indeed, there are new drugs in development that target metabolic pathways. Fungal sulfur metabolism is particularly interesting, as many of its processes are essential for viability and/or pathogenicity and it shows substantial differences with human metabolism. This short-review will summarize our current knowledge of sulfur-related genes and routes that are important for Aspergillus fumigatus virulence, which consequently could be pursued for drug development. #DrugDiscovery #DrugDevelopment #Fungus #Fungal #Fungi