Dolabellane Diterpenes and Elemane Alkaloids from the Soft Coral Clavularia inflata Collected in the South China Sea,Journal of Natural Products

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Dolabellane Diterpenes and Elemane Alkaloids from the Soft Coral Clavularia inflata Collected in the South China Sea
Journal of Natural Products ( IF 5.1 ) Pub Date : 2022-01-12 , DOI: 10.1021/acs.jnatprod.1c01103
Xiao Han _{1,

2} , Xiangchao Luo _{1,

2} , Lei Xue _{1,

2} , Leen van Ofwegen ₃ , Wenjie Zhang _{1,

2} , Kechun Liu ₄ , Yun Zhang ₄ , Xuli Tang ₅ , Pinglin Li _{1,

2} , Guoqiang Li _{1,

2}

Affiliation

Five new dolabellane diterpenes, clavularinlides A–E (1–5), and four new racemic elemane alkaloids, clavulacylides A–D (7–10), together with one known compound (6), were isolated from the soft coral Clavularia inflata collected in the South China Sea. Their structures were elucidated by 1D and 2D NMR, HRESIMS, calculated ECD, and DP4+ probability analyses. Compounds 1–7 showed anti-inflammatory activity in the zebrafish assay.

更新日期：2022-01-28

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