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Fig. 1.
Transendothelial transport regulated by membrane proteins. Membrane proteins participate in molecular transport through the vascular endothelium, where the transport pathway is determined by the size and polarity of the substance. Molecular transport relies on 2 pathways: paracellular transport, involving VE-cadherin and integrin, and transcellular transport, which is divided into passive diffusion and membrane-associated transport that involves caveolin (adsorptive transcytosis), Tf receptor (receptor-mediated transcytosis), and PV-1 (transendothelial channel).
VE, vascular endothelial; Tf, transferrin; PV-1, plasmalemmal vesicle associated protein-1; VEGFR, vascular endothelial growth factor receptor; ECM, extracellular matrix.
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