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Synthetic hydroxyapatite crystals

IV. Magnesium incorporation

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Abstract

Apatite crystals were synthesized under approximately physiological conditions and in the presence of magnesium ions. After ageing from 4 to 21 days, the crystals were analyzed and their exchange of incorporated magnesium studied with the use of28Mg.

Both the kinetics and the extent of the exchange showed that magnesium ions were strongly rejected by the apatite lattice. In aged crystals, nearly 90% of the magnesium was located in readily exchangeable (surface) positions. These findings support one concept that apatitic magnesium is essentially a surface-limited ion and help to explain the ready availability of skeletal magnesium in animals on magnesium deficient diets.

Résumé

Des cristaux d'apatite sont synthétisés dans des conditions physiological approximatives et en présence d'ions de magnésium. Après vieillissement de 4 à 21 jours, les cristaux sont analysés et l'échange du magnésium incorporé est étudié à l'aide de28Mg.

A la fois, l'étude cinétique et l'ampleur des échanges indiquent que les ions de magnésium sont nettement rejetés de la maille de l'apatite. Au niveau de vieux cristaux, près de 90% du magnésium est situé dans des positions (de surface) échangeables. Ces résultats confirment la théorie qui admet que le magnésium de l'apatite est surtout un ion de surface. Ils expliquent la grande labilité du magnésium squelettique chez des animaux soumis à des régimes pauvres en magnésium.

Zusammenfassung

Apatitkristalle wurden unter annähernd physiologischen Bedingungen und in Anwesenheit von Magnesiumionen synthetisiert. Nach einer Ausreifungszeit von 4–21 Tagen wurden die Kristalle und der Austausch des eingebauten Magnesiums mittels28Mg untersucht.

Sowohl die Kinetik als auch das Ausmaß des Austausches zeigten, daß die Magnesiumionen vom Apatitgitter heftig abgestoßen werden. bie ausgereiften Kristallen waren nahezu 90% des Magnesiums leicht austauschbar an der Oberfläche gelagert. Durch diese Befunde wird ein Konzept unterstützt, wonach das im Apatit vorkommende Magnesium hauptsächlich ein oberflächengebundenes Ion ist. Ferner läßt sich dadurch erklären, weshalb bei magnesiumarm ernährten Tieren so leicht Magnesium aus dem Skelet verfügbar ist.

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Authors and Affiliations

  1. Department of Radiation Biology and Biophysics, School of Medicine and Dentistry, University of Rochester, 14620, Rochester, New York, U.S.A.

    W. F. Neuman & B. J. Mulryan

Authors
  1. W. F. Neuman
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  2. B. J. Mulryan
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Additional information

This work was supported in part by the U. S. Public Health Service Training Grant No. 1 T1 DE-175 and in part by the U. S. Atomic Energy Commissio Contract No. AT (30-1)-49 and has been assigned Report No. UR-49-1308.

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Neuman, W.F., Mulryan, B.J. Synthetic hydroxyapatite crystals. Calc. Tis Res. 7, 133–138 (1971). https://doi.org/10.1007/BF02062601

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  • DOI: https://doi.org/10.1007/BF02062601

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