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Angeborene Mechanismen der Infektabwehr

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Immunsystem und Infektiologie

Part of the book series: Handbuch der Molekularen Medizin ((HDBMOLEK,volume 4))

Zusammenfassung

Die wahrscheinlich wichtigste und — vom Standpunkt der Evolution aus gesehen — erste Aufgabe des Immunsystems ist es, eine effiziente Abwehr von krankmachenden Mikroorganismen durchzuführen. Parallel zur Zunahme der Langlebigkeit des Einzelindividuums hat sich ein komplexes Abwehrsystem entwickelt, das den Organismus mit einem humoralen und einem zellulären Abwehrsystemen versieht. Klassischerweise wird dabei eine Unterscheidung in ein unspezifisches, natürliches oder angeborenes Immunsystem auf der einen Seite und ein spezifisches oder adaptives Abwehrsystem auf der anderen Seite vorgenommen. Spezifität in diesem Sinn bedeutet, daß ein Antigen durch Antikörper oder den T-Zell-Rezeptor erkannt und anschließend durch diverse Eliminationsmechanismen neutralisiert und entfernt wird.

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  1. Hans Sprenger
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  2. Diethard Gemsa
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    Detlev Ganten  & Klaus Ruckpaul  & 

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Sprenger, H., Gemsa, D. (1999). Angeborene Mechanismen der Infektabwehr. In: Ganten, D., Ruckpaul, K. (eds) Immunsystem und Infektiologie. Handbuch der Molekularen Medizin, vol 4. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-07865-5_10

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