Unsiatem

• Indications

For the Chronic Management of Hyperuricemia in Patients with Gout or kidney stones

• Active Ingredients

Febuxostat 40mg film coated tablets

Febuxostat 80mg film coated tablets

• Mechanism of Action

- Unsiatem® inhibits both the oxidized and reduced form of XO

- Unsiatem® is a non-purine, selective and potent inhibitor of XO, 10-30 times

more than allopurinol, and has no effect on other enzymes involved

in purine or pyrimidine metabolism

XO = Xanthine Oxidase

XDH = Xanthine Dehydrogenase

- Unsiatem® is a Xanthine Oxidase (XO) inhibitor

• Dose

• Side Effects

The most common Adverse Reactions:

- Liver Function Abnormalities

- Nausea, Arthralgia, Rash and Dizziness

Unsiatem® is contraindicated in patients being treated with azathioprine or

6-mercaptopurine

• Precautions

- After initiation, gout flare frequently occurs; provide

prophylaxis with NSAIDs or colchicine upon

initiation and for ≤6 months

- May increase liver enzyme activity; obtain Liver

function tests at baseline and do not initiate if AST is

3x ULN with total bilirubin > 2x ULN

- Pregnancy and Breastfeeding

• Contraindications

Unsiatem® 40mg

Carton box contains 3 strips

each one contains 10 film coated tablets & insert leaflet

Unsiatem® 80mg

Carton box contains 3 strips

each one contains 10 film coated tablets & insert leaflet

• Package

• Storage

Store below 30°C in a dry place