Convenient synthesis of perhydrobenz[e]indene triketone, a key intermediate for the total synthesis of stelletins†
Xiaoyu
Liu, 
a
Xiaozhen
Jiao
*a
and
a
Xiaozhen
Jiao
*a
and
Abstract
A complementary strategy for the formal total synthesis of (±)-stelletins is reported. Key reactions include a diastereoselective Eschenmoser–Claisen rearrangement, a highly diastereoselective alkylation of decalin-nitrile, and an intramolecular [3 + 2] cycloaddition/N–O reductive bond cleavage to construct the strained functionalized tricyclic core of (±)-stelletins.
![Graphical abstract: Convenient synthesis of perhydrobenz[e]indene triketone, a key intermediate for the total synthesis of stelletins](/en/Image/Get?imageInfo.ImageType=GA&imageInfo.ImageIdentifier.ManuscriptID=D3OB00319A&imageInfo.ImageIdentifier.Year=2023)
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