Introduction

    Phosphoglycerate Mutase is an important enzyme in the glycolytic pathway.  This enzyme catalyzes the conversion of 3-Phosphoglycerate to 2-Phosphoglycerate.  In the glycolytic pathway, this step precedes the formation of phosphoenolpyruvate and then pyruvate.  The overall action of any mutase enzyme of this fashion is to move a phosphate group from one place on a molecule to another, which is the case with this enzyme.  This reaction requires a catalytic amount of 2,3-bisphosphoglycerate to be active.  The Gibbs free energy change (delta G) is +0.2.  This reaction does take place when phosphoglycerate mutase is present to catalyze the reaction, and the reaction is reversible.  The glycolytic reaction that is catalyzed is found below.

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