Case definition | Hospital admission of a patient aged ≥ 21 yr without evidence of severe respiratory illness and no alternative plausible diagnosis and involvement of 1 or more extrapulmonary organ systems:
| Patient aged < 21 yr with fevers > 38.0°C for ≥ 24 h, or report of subjective fever lasting ≥ 24 h with laboratory evidence of clinically severe illness requiring hospital admission with multisystem (≥ 2) organ involvement:
Cardiac Renal Respiratory Hematologic Gastrointestinal Dermatologic Neurologic
| Complete Kawasaki disease: Fevers ≥ 5 d AND ≥ 4 principal clinical features
Suspected incomplete Kawasaki disease: Fevers ≥ 5 d AND 2–3 compatible clinical criteria, or infants with fevers ≥ 7 d without other explanation. |
Supportive investigations and laboratory finding | Elevated CRP, ferritin, D dimer or IL-6 | Elevated CRP, ESR, fibrinogen, procalcitonin, D dimer, ferritin, lactate dehydrogenase or IL-6, elevated neutrophils, reduced lymphocytes and low albumin | CRP ≥ 3.0 mg/dL (or) ESR ≥ 40 mm/hr AND 1) Positive echocardiogram: From AHA criteria, (2) echocardiography is considered positive if any of 3 conditions are met:
Z score of left anterior descending coronary artery or right coronary artery ≥ 2.5; coronary artery aneurysm is observed; or ≥ 3 other suggestive features exist, including decreased left ventricular function, mitral regurgitation, pericardial effusion or Z scores in left anterior descending coronary artery or right coronary artery of 2–2.5 OR 2) ≥ 3 supportive laboratory findings (anemia for age, platelet count ≥ 450 000 after 7th day of fevers, albumin ≤ 3.0 g/dL, elevated alanine aminotransferase, leukocytes ≥ 15 000/mm3, or urine with ≥ 10 leukocyte/hpf) |
SARS-CoV-2 | Positive for current or previous SARS-CoV-2 infection (nucleic acid, antigen, or antibody) during admission or in the previous 12 wk | Positive for current or recent SARS-CoV-2 infection by RT-PCR, serology or antigen test, or exposure to a suspected or confirmed COVID-19 case within 4 wk before onset of symptoms | NA |