“Hassane is a highly motivated medicinal chemist that perseveres through difficult objectives and incorporates his solid understanding of target biochemistry into design of new chemical entities. Hassane and I worked together on a laborious chemical synthesis plan that other chemists abandoned because of its difficult synthesis. His persistence in obtaining sufficient compounds allowed us to obtain clear target validation, achieve a pharmacology decision, and to utilize contract synthesis to deliver sufficient compound for target co-crystallization.”
Hassane Belabed
South San Francisco, California, United States
497 followers
500+ connections
South San Francisco, California, United States
497 followers
500+ connections
Activity
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Are you an undergraduate student doing research, or do you have undergraduate research students in your lab? UCI’s Summer Undergraduate Research…
Are you an undergraduate student doing research, or do you have undergraduate research students in your lab? UCI’s Summer Undergraduate Research…
Liked by Hassane Belabed
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Indebted to Odyssey Therapeutics for supporting a stellar day of science at Scripps Research featuring Justin Du Bois, Arun Thottumkara, PhD, and…
Indebted to Odyssey Therapeutics for supporting a stellar day of science at Scripps Research featuring Justin Du Bois, Arun Thottumkara, PhD, and…
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Experience
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Education
Publications
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Development of selective inhibitors of phosphatidylinositol 3-kinase C2α
Nature Chemical Biology 2023, 19, 18-27
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Antagonistic control of active surface integrins by myotubularin and phosphatidylinositol 3-kinase C2β in a myotubular myopathy model
Proceedings of the National Academy of Sciences (PNAS) 2022, 40, e2202236119
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An LPAR5-antagonist that reduces nociception and increases pruriception
Frontiers in Pain Research 2022, 3, 963174
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Phosphoinositide conversion inactivates R-RAS and drives metastases in breast cancer
Advanced Science 2022, 9, 2103249
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Heterocyclic compounds as class II phosphoinositide 3-kinase inhibitors
Patent WO/2019/234237
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A pharmacological master key mechanism that unlocks the selectivity filter gate in K+ channels
Science 2019, 363, 875-880
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Transition-metal-free synthesis of borylated thiophenes via formal thioboration
Organic Letters 2018, 20, 6673-6677
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A general one‐pot synthesis of 2H‐indazoles using an organophosphorus‐silane system
Chemistry – A European Journal 2018, 24, 9090-9100
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Novel strategy for the preparation of 3- perfluoroalkylated-2H-indazole derivatives
Tetrahedron Letters 2018, 59, 1813-1815
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A straightforward approach to N-substituted-2H-indazol-2-amines through reductive cyclization
Tetrahedron Letters 2017, 58, 1633-1635
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Organophosphorus-mediated N-N bond formation: facile access to 3- amino-2H-indazoles
Organic & Biomolecular Chemistry 2016, 14, 8520-8528
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Simple approach to the synthesis of novel tricyclic BACE-1 inhibitor warhead through beta-lactam opening
Tetrahedron Letters 2015, 56, 4028-4030
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Organophosphorus-catalyzed Diaza-Wittig reaction: application to the synthesis of pyridazines
Organic & Biomolecular Chemistry 2014, 12, 7159-7166
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A novel and convenient strategy for the synthesis of phthalazines from an aryne precursor
Tetrahedron Letters 2013, 54, 7056-7058
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Strategy for the synthesis of pyridazine heterocycles and their derivatives
Journal of Organic Chemistry 2013, 78, 7845-7858
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Simple approach to the synthesis of 3-fluoro pyrazolo[1,5- a]pyrimidine analogues
Tetrahedron Letters 2013, 54, 2612-2614
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A short and convenient strategy for the synthesis of pyridazines via Diaza-Wittig reaction
Tetrahedron Letters 2012, 53, 6489-6491
Honors & Awards
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Travel Grant
European Lead Factory
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IWT-Baekeland PhD Fellowship
Agentschap voor Innovatie door Wetenschap en Technologie
Languages
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French
Native or bilingual proficiency
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English
Full professional proficiency
Recommendations received
2 people have recommended Hassane
Join now to viewMore activity by Hassane
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Our last article has been just posted in ChemRxiv. Discover this novel automated synthesis approach that allows the combination of 3 elements on line…
Our last article has been just posted in ChemRxiv. Discover this novel automated synthesis approach that allows the combination of 3 elements on line…
Liked by Hassane Belabed
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Congrats to Prof. Jin-Quan Yu, PhD, the Bristol Myers Squibb Endowed Chair in Chemistry and the Frank and Bertha Hupp Professor in Chemistry at…
Congrats to Prof. Jin-Quan Yu, PhD, the Bristol Myers Squibb Endowed Chair in Chemistry and the Frank and Bertha Hupp Professor in Chemistry at…
Liked by Hassane Belabed
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Pretty interesting to read, "Next-generation anti-PD-L1/IL-15 immunocytokine elicits superior antitumor immunity in cold tumors with minimal…
Pretty interesting to read, "Next-generation anti-PD-L1/IL-15 immunocytokine elicits superior antitumor immunity in cold tumors with minimal…
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A fruitful collaboration between the team LOMAC and WaveCoRE KU Leuven. Highly modular PDMS microwave-microfluidic chip reactor for MAOS applications…
A fruitful collaboration between the team LOMAC and WaveCoRE KU Leuven. Highly modular PDMS microwave-microfluidic chip reactor for MAOS applications…
Liked by Hassane Belabed
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We are excited to share our work on a scalable protocol for removing triphenylphosphine oxide (TPPO) from reaction mixtures, which was just published…
We are excited to share our work on a scalable protocol for removing triphenylphosphine oxide (TPPO) from reaction mixtures, which was just published…
Liked by Hassane Belabed
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A straightforward, metal-free, and acid-/base-free electrochemical C4-selective C − H deuteration of pyridine derivatives with economic and…
A straightforward, metal-free, and acid-/base-free electrochemical C4-selective C − H deuteration of pyridine derivatives with economic and…
Liked by Hassane Belabed
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Boron is an element that has been overlooked during evolution: it is not found in any natural enzyme. However, chemists have used boron reagents and…
Boron is an element that has been overlooked during evolution: it is not found in any natural enzyme. However, chemists have used boron reagents and…
Liked by Hassane Belabed
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A big thank you to all our speakers at what has been a fantastic symposium today! New Modalities:Innovation in Peptides as therapeutics…
A big thank you to all our speakers at what has been a fantastic symposium today! New Modalities:Innovation in Peptides as therapeutics…
Liked by Hassane Belabed
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Synthesis of Fused Triazoles from readily available chiral cyclopropanols. Radical ring-opening coupling of Cyclopropanol with 1,2,3-Triazole. A…
Synthesis of Fused Triazoles from readily available chiral cyclopropanols. Radical ring-opening coupling of Cyclopropanol with 1,2,3-Triazole. A…
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LiBr assisted C-H insertion ... J. Org. Chem., ASAP https://lnkd.in/dGzkh_pP
LiBr assisted C-H insertion ... J. Org. Chem., ASAP https://lnkd.in/dGzkh_pP
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