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Receptor seeks ligand: On the way to cloning the molecular receptors for sweet and bitter taste

Abstract

The cloning of two new taste receptors represents a scrumptious advance for this field of research, but determining their flavor still leaves one feeling slightly hungry

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Figure 1: Chemotopic representation of the human tongue according to Hänig, the first source on tongue maps10.

References

  1. Hoon, M.A. et al. Putative mammalian taste receptors: A class of taste specific GPCRs with distinct topographic selectivity. Cell 96 , 541–551 (1999).

    Article  CAS  Google Scholar 

  2. Wong, G.T., Gannon, K.S. & Margolskee, R.F. Transduction of bitter and sweet taste by gustducin. Nature 381, 796–800 (1996).

    Article  CAS  Google Scholar 

  3. Lindemann, B. Taste reception. Physiol. Rev. 76, 719– 766 (1996).

    Article  CAS  Google Scholar 

  4. Ozaki, M., Amakawa, T., Ozaki, K. & Tokunaga, F. Two types of sugar-binding protein in the labellum of the fly - putative taste receptor molecules for sweetness. J. Gen. Physiol. 102, 201–216 (1993).

    Article  CAS  Google Scholar 

  5. Grosvenor, W. et al. The arginine taste receptor. Physiology, biochemistry, and immunohistochemistry. Ann NY Acad. Sci. 855, 134–142 (1998).

    Article  CAS  Google Scholar 

  6. Abe, K., Kusakabe, Y., Tanemura, K., Emori, Y. & Arai, S. Primary structure and cell-type specific expression of a gustatory G protein-coupled receptor related to olfactory receptors. J. Biol. Chem. 268, 12033– 12039 (1993).

    CAS  PubMed  Google Scholar 

  7. Matsuoka, I., Mori, T., Aoki, J., Sato, T. & Kurihara, K. Identification of novel members of G-protein coupled receptor superfamily expressed in bovine taste tissue. Biochem. Biophys. Res. Comm. 194, 504–511 (1993).

    Article  CAS  Google Scholar 

  8. Chaudhari, N. et al. The Taste of Monosodium Glutamate: Membrane receptors in taste buds. J. Neurosci. 16, 3817– 3826 (1996).

    Article  CAS  Google Scholar 

  9. Landin, A.M. & Chaudhari, N. Functional expression of brain- and taste-specific forms of metabotropic glutamate receptor 4 (mGluR4) in cultured Chinese Hamster Ovary (CHO) cells. Chem. Senses (in the press).

  10. Hänig, D.P. Zur Psychophysik des Geschmackssinnes. Philosophische Studien 17, 576–623 (1901).

    Google Scholar 

  11. Smith, D.V. & Frank, M.E. Sensory coding by peripheral taste fibers. in Chapter 12: Mechanisms of Taste Transduction (eds. Simon, S.A. & Roper, S.D.) 295–338 (CRC Press, Boca Raton, 1993).

    Google Scholar 

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Lindemann, B. Receptor seeks ligand: On the way to cloning the molecular receptors for sweet and bitter taste. Nat Med 5, 381–382 (1999). https://doi.org/10.1038/7377

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